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Tag: Cancer research

Interview & Opinion

22 June 2022

A cell protein like a bull in a china shop

Interview: Alois Pumhösel

If the protein legumain is not in its proper place in the human cell, the likely result is cancer or Alzheimer’s disease. Molecular biologist and START prize winner Elfriede Dall from the University of Salzburg is investigating how this protein functions outside of its usual environment.    Continue reading “A cell protein like a bull in a china shop”

Interview & Opinion

22 June 2021

Taking the antibody taxi right into the cancer cell

Interview: Juliane Fischer

START Award winner Hannes Mikula is a chemist who works at the interface between chemistry and biology and wants to improve cancer therapy. His goal is to steer active substances directly into the tumour cell. In this way, the substances do not attack healthy cells and destroy specifically the cancer cells. Continue reading “Taking the antibody taxi right into the cancer cell”

Projects

3 May 2021

Implant to improve therapy of brain tumours

Despite surgery and subsequent treatment with chemotherapy and radiation, the majority of patients experience recurrence of malignant brain tumours. Research groups from Sweden and Austria have shown in cells in culture that an ion pump can deliver drugs more accurately, which gives less severe adverse effects in chemotherapy. The results have been published in Advanced […] Continue reading “Implant to improve therapy of brain tumours”

Projects

25 May 2020

How cancer cells defend themselves against radiotherapy

Cancer stem cells are a cell type that was previously little known. They are resistant to irradiation and prevent the effective treatment of many types of cancer. A research group from Innsbruck has now identified two genetic mechanisms that produce this radioresistance. Continue reading “How cancer cells defend themselves against radiotherapy”

Projects

12 August 2019

How “good cholesterol” gets to do even more good work

In order for a tumour to grow, it needs cholesterol to build new cell walls. At the same time, the so-called “good” cholesterol or high-density lipoprotein (HDL) is regarded as a protective factor against cancer. Schrödinger fellow Raimund Bauer investigated the effect of HDL on tumours more closely and was able to show that a […] Continue reading “How “good cholesterol” gets to do even more good work”

Projects

15 April 2019

From metabolite profiles to molecular biomarkers for colorectal cancer

The aim of a European project (TRANSCAN) is to identify metabolite signatures that are associated with all stages in the development of colorectal cancer. Metabolomic analysis was performed on more than 2,000 plasma samples from individuals with colorectal cancer, colorectal adenoma and a control group.   Continue reading “From metabolite profiles to molecular biomarkers for colorectal cancer”

Projects

12 November 2018

A power couple mobilises cancer cells

The ILEI protein transforms sedentary into mobile cells and is therefore regarded as an important signal inducer for the metastasis of cancer cells. ILEI is only one member of a protein family that has not been widely researched. With the support of the Austrian Science Fund FWF, cancer researcher Agnes Csiszar has demonstrated that one […] Continue reading “A power couple mobilises cancer cells”

Projects

17 September 2018

Luminescent nanoparticles help with early cancer detection

In a project funded by the FWF, a research group from Innsbruck investigated how cancer cells in the large intestine can be made to glow in order to facilitate early detection. Continue reading “Luminescent nanoparticles help with early cancer detection”

Projects

30 July 2018

Proven biochemistry methods for new skin cancer therapy

Like all other cells in the body, skin cancer cells need a cholesterol metabolism. With the support of the Austrian Science Fund FWF, a Viennese research group discovered deviations and particularities of this process in malignant melanoma that could help improve prognosis and therapy. Continue reading “Proven biochemistry methods for new skin cancer therapy”

Projects

28 May 2018

Discovery of new mechanism for tumour suppression

A group of researchers from Innsbruck has been the first to describe how damaged cells can be inhibited from multiplying further after incomplete division. In a project funded by the FWF, the team disproved the previous assumption that the mechanism is triggered by defective genetic information. Continue reading “Discovery of new mechanism for tumour suppression”

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